Breast Cancer

E0771 Cell Line: E0771 is a murine (mouse) breast cancer cell line derived from a spontaneously occurring tumor in C57BL/6 mice. It is often used in research as a model for triple-negative breast cancer, which lacks estrogen, progesterone, and HER2 receptors. This cell line is valuable for studying aggressive breast cancer subtypes and evaluating potential treatments in an immunocompetent setting.

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4T1 Cell Line: The 4T1 cell line is another murine breast cancer model, derived from a mammary tumor in BALB/c mice. It closely mimics stage IV human breast cancer due to its highly metastatic nature, spreading to multiple organs such as the lungs, liver, and brain.

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MDA-MB-231 Cell line: MDA-MB-231 cells are a human breast cancer cell line that is commonly used in scientific research, particularly in the study of triple-negative breast cancer (TNBC). These cells were originally isolated from the pleural effusion of a patient with metastatic breast cancer in the 1970s.